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KMID : 0882420120820030341
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Korean Journal of Medicine
2012 Volume.82 No. 3 p.341 ~ p.346
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Protease Inhibitor Treatment of Disseminated Intravascular Coagulation Associated with Aortic Dissection
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Ko Sung-Min
Kim Nam-Jun
Kim Chung-Hun
Cho Jin-Hyun
Lee Eun-Young
Huh Kyung-Min
Kim Duk-Kyung
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Abstract
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Disseminated intravascular coagulation (DIC) is a rare complication of aortic dissection. We report an unusual case of a 64-year-old woman with DIC associated with chronic aortic dissection who developed catastrophic intracranial hemorrhage. Computed tomography (CT) revealed partially thrombosed false lumen in the chronic dissected aneurysm of the thoracoabdominal aorta, which remained after surgery for acute type A aortic dissection. The laboratory profile showed features of DIC, including thrombocytopenia, hypofibrinogenemia, and increased D-dimer levels. Bleeding diathesis, including ecchymosis and coagulopathy, showed improvement following treatment with protease inhibitors (nafamostat and camostat).
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KEYWORD
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Aortic dissection, Disseminated intravascular coagulation, Protease inhibitor, Nafamostat mesilate, Heparin
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